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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2003 1
2004 1
2005 1
2007 4
2008 3
2009 4
2010 8
2011 16
2012 11
2013 10
2014 19
2015 15
2016 24
2017 24
2018 20
2019 29
2020 29
2021 45
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2023 45
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322 results

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Page 1
Mitochondrial Fusion Protein Mfn2 and Its Role in Heart Failure.
Chen L, Liu B, Qin Y, Li A, Gao M, Liu H, Gong G. Chen L, et al. Front Mol Biosci. 2021 May 7;8:681237. doi: 10.3389/fmolb.2021.681237. eCollection 2021. Front Mol Biosci. 2021. PMID: 34026850 Free PMC article. Review.
Mitofusin 2 (Mfn2) is a transmembrane GTPase located on the mitochondrial outer membrane that contributes to mitochondrial network regulation. ...Here, this review mainly focuses on what is known about the structure and function of Mfn2 and its crucial role in he …
Mitofusin 2 (Mfn2) is a transmembrane GTPase located on the mitochondrial outer membrane that contributes to mitochondrial network re …
USP28 Serves as a Key Suppressor of Mitochondrial Morphofunctional Defects and Cardiac Dysfunction in the Diabetic Heart.
Xie SY, Liu SQ, Zhang T, Shi WK, Xing Y, Fang WX, Zhang M, Chen MY, Xu SC, Fan MQ, Li LL, Zhang H, Zhao N, Zeng ZX, Chen S, Zeng XF, Deng W, Tang QZ. Xie SY, et al. Circulation. 2024 Feb 27;149(9):684-706. doi: 10.1161/CIRCULATIONAHA.123.065603. Epub 2023 Nov 23. Circulation. 2024. PMID: 37994595
RESULTS: Microarray profiling of the UPS (ubiquitin-proteasome system) on the basis of db/db mouse hearts and diabetic patients' hearts demonstrated that the diabetic ventricle presented a significant reduction in USP28 expression. ...However, such cardioprotective …
RESULTS: Microarray profiling of the UPS (ubiquitin-proteasome system) on the basis of db/db mouse hearts and diabetic patients' h …
The AMPK-MFN2 axis regulates MAM dynamics and autophagy induced by energy stresses.
Hu Y, Chen H, Zhang L, Lin X, Li X, Zhuang H, Fan H, Meng T, He Z, Huang H, Gong Q, Zhu D, Xu Y, He P, Li L, Feng D. Hu Y, et al. Autophagy. 2021 May;17(5):1142-1156. doi: 10.1080/15548627.2020.1749490. Epub 2020 Apr 19. Autophagy. 2021. PMID: 32249716 Free PMC article.
Interestingly, under energy stress, considerable amounts of AMPK translocate from cytosol to the MAM and the mitochondrion as mitochondrial fission occurs. Unexpectedly, AMPK interacts directly with MFN2. The autophagic ability of mouse embryonic fibroblasts (MEFs) lacking …
Interestingly, under energy stress, considerable amounts of AMPK translocate from cytosol to the MAM and the mitochondrion as mitochondrial …
Omentin1 ameliorates myocardial ischemia-induced heart failure via SIRT3/FOXO3a-dependent mitochondrial dynamical homeostasis and mitophagy.
Hu J, Liu T, Fu F, Cui Z, Lai Q, Zhang Y, Yu B, Liu F, Kou J, Li F. Hu J, et al. J Transl Med. 2022 Oct 4;20(1):447. doi: 10.1186/s12967-022-03642-x. J Transl Med. 2022. PMID: 36192726 Free PMC article.
However, the protective effect of omentin1 in myocardial ischemia (MI)-induced heart failure (HF) and its specific mechanism remains unclear and to be elucidated. ...This study provides evidence for further application of omentin1 in cardiovascular diseases from the perspe …
However, the protective effect of omentin1 in myocardial ischemia (MI)-induced heart failure (HF) and its specific mechanism remains …
Dysregulation of Mfn2 and Drp-1 proteins in heart failure.
Givvimani S, Pushpakumar S, Veeranki S, Tyagi SC. Givvimani S, et al. Can J Physiol Pharmacol. 2014 Jul;92(7):583-91. doi: 10.1139/cjpp-2014-0060. Epub 2014 May 9. Can J Physiol Pharmacol. 2014. PMID: 24905188 Free PMC article. Review.
We recently observed that the ratio of mitofusin 2 (Mfn2; a fusion protein) and Drp-1 (a fission protein) was decreased during heart failure, suggesting increased mitophagy. ...In this review, we discuss mitochondrial dynamics, its relation to MMP-9 and Cx-43, and t …
We recently observed that the ratio of mitofusin 2 (Mfn2; a fusion protein) and Drp-1 (a fission protein) was decreased during hea …
Overexpression of MFN2 alleviates sorafenib-induced cardiomyocyte necroptosis via the MAM-CaMKIIdelta pathway in vitro and in vivo.
Song Z, Song H, Liu D, Yan B, Wang D, Zhang Y, Zhao X, Tian X, Yan C, Han Y. Song Z, et al. Theranostics. 2022 Jan 1;12(3):1267-1285. doi: 10.7150/thno.65716. eCollection 2022. Theranostics. 2022. PMID: 35154486 Free PMC article.
Excess MAM formation and close ER-mitochondria contact were key pathogenesis of sor-induced Ca(2+) overload. Sor mediated MFN2 downregulation in a concentration-dependent manner. Furthermore, we found that reduced mitofusin-2 (MFN2) level augmented sor-mediated elev …
Excess MAM formation and close ER-mitochondria contact were key pathogenesis of sor-induced Ca(2+) overload. Sor mediated MFN2 downre …
Mitochondrial Dynamics and Mitophagy in Cardiometabolic Disease.
Lin J, Duan J, Wang Q, Xu S, Zhou S, Yao K. Lin J, et al. Front Cardiovasc Med. 2022 Jun 17;9:917135. doi: 10.3389/fcvm.2022.917135. eCollection 2022. Front Cardiovasc Med. 2022. PMID: 35783853 Free PMC article. Review.
This paper reviewed the mechanisms of mitochondrial dynamics and mitophagy (focus on MFN1, MFN2, OPA1, DRP1, and PINK1 proteins) and their roles in diabetic cardiomyopathy, myocardial infarction, cardiac hypertrophy, heart failure, atherosclerosis, and obesity....
This paper reviewed the mechanisms of mitochondrial dynamics and mitophagy (focus on MFN1, MFN2, OPA1, DRP1, and PINK1 proteins) and …
DIAPH1-MFN2 interaction regulates mitochondria-SR/ER contact and modulates ischemic/hypoxic stress.
Yepuri G, Ramirez LM, Theophall GG, Reverdatto SV, Quadri N, Hasan SN, Bu L, Thiagarajan D, Wilson R, Díez RL, Gugger PF, Mangar K, Narula N, Katz SD, Zhou B, Li H, Stotland AB, Gottlieb RA, Schmidt AM, Shekhtman A, Ramasamy R. Yepuri G, et al. Nat Commun. 2023 Oct 30;14(1):6900. doi: 10.1038/s41467-023-42521-x. Nat Commun. 2023. PMID: 37903764 Free PMC article.
Solution structure studies affirm the interaction between the Diaphanous Inhibitory Domain and the cytosolic GTPase domain of MFN2. In male rodent and human cardiomyocytes, DIAPH1-MFN2 interaction regulates mitochondrial turnover, mitophagy, and oxidative stress. .. …
Solution structure studies affirm the interaction between the Diaphanous Inhibitory Domain and the cytosolic GTPase domain of MFN2. I …
Neuronal Mitochondria Modulation of LPS-Induced Neuroinflammation.
Harland M, Torres S, Liu J, Wang X. Harland M, et al. J Neurosci. 2020 Feb 19;40(8):1756-1765. doi: 10.1523/JNEUROSCI.2324-19.2020. Epub 2020 Jan 14. J Neurosci. 2020. PMID: 31937559 Free PMC article.
LPS-induced release of IL-1beta but not TNF-alpha was further found greatly inhibited in the CNS of mice with neuronal Mfn2 overexpression, whereas peripheral inflammatory responses in the blood, heart, lung, and spleen remained unchanged. ...The pharmacological tar …
LPS-induced release of IL-1beta but not TNF-alpha was further found greatly inhibited in the CNS of mice with neuronal Mfn2 overexpre …
Mitochondrial autophagy and cell survival is regulated by the circadian Clock gene in cardiac myocytes during ischemic stress.
Rabinovich-Nikitin I, Rasouli M, Reitz CJ, Posen I, Margulets V, Dhingra R, Khatua TN, Thliveris JA, Martino TA, Kirshenbaum LA. Rabinovich-Nikitin I, et al. Autophagy. 2021 Nov;17(11):3794-3812. doi: 10.1080/15548627.2021.1938913. Epub 2021 Aug 7. Autophagy. 2021. PMID: 34085589 Free PMC article.
The circadian Clock gene is critically linked to vital physiological processes including mitochondrial fission, fusion and bioenergetics; however, little is known of how the Clock gene regulates these vital processes in the heart. Herein, we identified a putative circadian …
The circadian Clock gene is critically linked to vital physiological processes including mitochondrial fission, fusion and bioenergetics; ho …
322 results